Comparative characteristics of histological changes in lung tissue in rats of different ages under conditions of hyperhomocysteinemia

Annotation. Defeat of the respiratory system is a common phenomenon in today's conditions. Elevated levels homocysteine (Hz) are one predictors bronchopulmonary pathology. In recent years, there has been an association between its concentration blood plasma and risk developing COPD, bronchial asthma, lung cancer. The pathogenesis damage hyperhomocysteinemia (GHz) still being studied, but it known to be cause endothelial dysfunction, oxidative stress, endoplasmic reticulum which underlie tissue damage. aim study establish comparative characterization histological changes rats different ages at GHz. experimental was performed on 64 white nonlinear male rats. During experiment, animals were divided into two groups – control experimental, each subgroups depending age young (1-2 months), mature (6-8 old (24-26 months). Simulation stable GHz state achieved by administering group thiolactone Hz dose 200 mg/kg body weight intragastrically for 60 days. Histological specimens studied using SEO CCAN light microscope photo-documented Vision CCD Camera with image output from specimens. examinations lungs under conditions revealed moderate destructive vessels, bronchi, components department, compensatory-adaptive reversible. Adaptive-compensatory organ found adult Older develop most significant destructive-degenerative compared studies defining feature this excessive activation fibroblasts development perivascular, peribronchial, interstitial sclerosis.